Background Treatment outcomes for multidrug-resistant tuberculosis remain poor. We aimed
to estimate the association of treatment success and death with the use of individual drugs …

Binuclear metallohydrolases are a structurally diverse group of enzymes that use binuclear
metal ion centers to catalyze the hydrolysis of amides and esters of carboxylic and …

The influx of attention regarding psychopathy in the workplace by media and scholars alike
has increased dramatically over the last two decades. Nevertheless, this attention has …

The compact genome of Fugu rubripes has been sequenced to over 95% coverage, and
more than 80% of the assembly is in multigene-sized scaffolds. In this 365-megabase …

RNA-binding proteins are key regulators of gene expression, yet only a small fraction have
been functionally characterized. Here we report a systematic analysis of the RNA motifs …

In addition to protein coding sequence, the human genome contains a significant amount of
regulatory DNA, the identification of which is proving somewhat recalcitrant to both in silico …

Current sampling of genomic sequence data from eukaryotes is relatively poor, biased, and
inadequate to address important questions about their biology, evolution, and ecology; this …

The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus
can spread and the ability of a generally mild infection to induce severe morbidity and …

The nature and scale of the shocks to the demand for, and the supply of, home childcare
during the COVID-19 pandemic provide a unique opportunity to increase our understanding …

This report estimates historical data center electricity consumption back to 2000, relying on
previous studies and historical shipment data, and forecasts consumption out to 2020 based …