We review the characteristics of osteoblast differentiation and bone matrix synthesis. Bone in
air breathing vertebrates is a specialized tissue that developmentally replaces simpler solid …

The osteoclast is a monocyte-derived cell with complex regulatory control due to its role,
balancing calcium homeostasis with skeletal modelling and repair. Normal differentiation …

The value of mortality risk reduction is an important component of the benefits of
environmental policies. In recent years, the number, scope, and quality of valuation studies …

Endothelial nitric-oxide synthase (eNOS) generates the key signaling molecule nitric oxide
in response to intralumenal hormonal and mechanical stimuli. We designed studies to …

Leukocyte migration into sites of inflammation involves multiple molecular interactions
between leukocytes and vascular endothelial cells, mediating sequential leukocyte capture …

The relationships between normal and leukemic stem/progenitor cells are unclear. We show
that in∼ 80% of primary human CD34+ acute myeloid leukemia (AML), two expanded …

The income elasticity of the value per statistical life (VSL) is an important parameter for
policy analysis. Mortality risk reductions often dominate the quantified benefits of …

In nonneuronopathic type 1 Gaucher disease (GD1), mutations in the glucocerebrosidase
gene (GBA1) gene result in glucocerebrosidase deficiency and the accumulation of its …

Background—Cardiac consequences of obesity include inflammation, hypertrophy, and
compromised energy metabolism. Glucagon-like peptide-1 is an incretin hormone capable …

Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension
associated with fibrotic occlusion of the smaller pulmonary veins. Although vasodilator …